Cyclosporin A, >99% , 1g-100g, CAS#59865-13-3
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Cyclosporin A, >99% , 1g-100g, CAS#59865-13-3

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    BC020-1g
Cyclosporin A, >99%
Synonyms: CsA, Ciclosporin, Cyclosporine, Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A

CAS#59865-13-3, M.W.1202.61, Formula: C62H111N11O12


Cat.# Size Price ($)
BC020-1g 1 g 45
BC020-5g 5 g 135
BC020-10g 10 g 209
BC020-25g 25 g 499
BC020-100g 100 g 1025
Cyclosporin A, ciclosporin, cyclosporine, cyclosporin is an immunosuppressant reagent which is used to lower the activity of T cells and their immune response.

Cyclosporin A
binds to the cytosolic protein cyclophilin (immunophilin) of lymphocytes, especially T cells. This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor nuclear factor of activated T-cells (NFATc), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Ciclosporin prevents the dephosphorlyation of NF-AT by binding to cyclophilin. It also inhibits lymphokine production and interleukin release and, therefore, leads to a reduced function of effector T-cells. It does not affect cytostatic activity.

Cyclosporin A affects mitochondria by preventing the mitochondrial permeability transition pore from opening, thus inhibiting cytochrome c release, a potent apoptotic stimulation factor. This is not the primary mechanism of action for clinical use, but is an important effect for research on apoptosis.

Reference:
  1. William F. Ganong. Review of medical physiology, 22nd edition, Lange medical books, chapter 27, page 530. ISBN 0-07-144040-2
  2. Henry ML, Elkhammas EA, Davies EA, Ferguson RM (1995). "A clinical trial of cyclosporine G in cadaveric renal transplantation". Pediatr. Nephrol. 9 (Suppl): S49–51. doi:10.1007/BF00867684. PMID 7492487.
  3. Lim HW, De Windt LJ, Mante J, et al. (April 2000). "Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition". J. Mol. Cell. Cardiol. 32 (4): 697–709. doi:10.1006/jmcc.2000.1113. PMID 10756124.
  4. Calcineurin inhibitor nephrotoxicity". Clin. J. Am. Soc. Nephrol. 4 (2): 481–509. doi:10.2215/CJN.04800908. PMID 19218475.
  5. Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW (November 1984). "Cyclophilin: a specific cytosolic binding protein for cyclosporin A". Science 226 (4674): 544–7. doi:10.1126/science.6238408. PMID 6238408.
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