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BIOTANG Inc. :: >Reagent :: Rapamycin, >99%, 200mg-5g (Sirolimus)

Rapamycin, >99%, 200mg-5g (Sirolimus)
Rapamycin, >99%, 200mg-5g (Sirolimus) 

This product has been quoted by :
1.mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats.>> Pubmed link

Rapamycin, >99%
Synonyms:  Sirolimus; AY-22989; LCP-Siro; RAPA; Rapamune; SILA 9268A

CAS#53123-88-9, M.W.914.17, Formula: C51H79NO13

Cat.# Size Price ($)
R1017-200mg 200 mg 99
R1017-300mg 300 mg 139
R1017-500mg 500 mg 219
R1017-1g 1 g 409
R1017-2g 2 g 699
R1017-5g 5 g 1399
Rapamycin, also known as sirolimus, is especially useful in kidney transplants. It prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2). Unlike the similarly named tacrolimus, sirolimus is not a calcineurin inhibitor, but it has a similar suppressive effect on the immune system. Sirolimus inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T- and B-cells. In contrast, tacrolimus inhibits the secretion of IL-2.

The mode of action of sirolimus is to bind the cytosolic protein FK-binding protein 12 (FKBP12) in a manner similar to tacrolimus. Unlike the tacrolimus-FKBP12 complex which inhibits calcineurin (PP2B), though, the sirolimus-FKBP12 complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1).


  • 1. Vézina C, Kudelski A, Sehgal SN (October 1975). "Rapamycin (AY-22,989), a new antifungal antibiotic". J. Antibiot. 28 (10): 721\u20136. PMID 1102508.
  • 2. Pritchard DI (2005). "Sourcing a chemical succession for cyclosporin from parasites and human pathogens". Drug Discovery Today 10 (10): 688–691. doi:10.1016/S1359-6446(05)03395-7. PMID 15896681.
  • 3. Shuchman M (2006). "Trading restenosis for thrombosis? New questions about drug-eluting stents". N Engl J Med 355 (19): 1949–52. doi:10.1056/NEJMp068234. PMID 17093244
  • 4. Das BB, Shoemaker L, Subramanian S, Johnsrude C, Recto M, Austin EH (March 2007). "Acute sirolimus pulmonary toxicity in an infant heart transplant recipient: case report and literature review". J. Heart Lung Transplant. 26 (3): 296–8. doi:10.1016/j.healun.2006.12.004. PMID 17346635.

  •   78%

    CATALOG# R1017-200mg
    Weight 0.00 lbs
    Price: $99.00

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