Quick Order
your Cart
Help For New Users
Contact Us
Search: Advanced search      CALL US: 1-866-897-4664   FAX: 1-866-884-0576  
Printable version 
Categories Categories
>cDNA Clones
>Recombinant Protein
>Tissue Microarray
>Ubiquitin products
>Reagent Kit
>Buffer & Medium
>Protein Marker
>DNA Markers
>Other Labware
>Monthly Deals
>Animal Surgical Service

Suppliers Suppliers
TSZ Scientific LLC
Boston BioProducts Inc
Sorenson Inc.
Sorenson Avant

Other manufacturers...

BIOTANG Inc. :: >Reagent :: Rapamycin, >99%, 200mg-5g (Sirolimus)

Rapamycin, >99%, 200mg-5g (Sirolimus)
Rapamycin, >99%, 200mg-5g (Sirolimus) 

This product has been quoted by :
1.mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats.>> Pubmed link

Rapamycin, >99%
Synonyms:  Sirolimus; AY-22989; LCP-Siro; RAPA; Rapamune; SILA 9268A

CAS#53123-88-9, M.W.914.17, Formula: C51H79NO13

Cat.# Size Price ($)
R1017-200mg 200 mg 99
R1017-300mg 300 mg 139
R1017-500mg 500 mg 219
R1017-1g 1 g 409
R1017-2g 2 g 699
R1017-5g 5 g 1399
Rapamycin, also known as sirolimus, is especially useful in kidney transplants. It prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2). Unlike the similarly named tacrolimus, sirolimus is not a calcineurin inhibitor, but it has a similar suppressive effect on the immune system. Sirolimus inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T- and B-cells. In contrast, tacrolimus inhibits the secretion of IL-2.

The mode of action of sirolimus is to bind the cytosolic protein FK-binding protein 12 (FKBP12) in a manner similar to tacrolimus. Unlike the tacrolimus-FKBP12 complex which inhibits calcineurin (PP2B), though, the sirolimus-FKBP12 complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1).


  • 1. Vézina C, Kudelski A, Sehgal SN (October 1975). "Rapamycin (AY-22,989), a new antifungal antibiotic". J. Antibiot. 28 (10): 721\u20136. PMID 1102508.
  • 2. Pritchard DI (2005). "Sourcing a chemical succession for cyclosporin from parasites and human pathogens". Drug Discovery Today 10 (10): 688–691. doi:10.1016/S1359-6446(05)03395-7. PMID 15896681.
  • 3. Shuchman M (2006). "Trading restenosis for thrombosis? New questions about drug-eluting stents". N Engl J Med 355 (19): 1949–52. doi:10.1056/NEJMp068234. PMID 17093244
  • 4. Das BB, Shoemaker L, Subramanian S, Johnsrude C, Recto M, Austin EH (March 2007). "Acute sirolimus pulmonary toxicity in an infant heart transplant recipient: case report and literature review". J. Heart Lung Transplant. 26 (3): 296–8. doi:10.1016/j.healun.2006.12.004. PMID 17346635.

  •   78%

    CATALOG# R1017-200mg
    Weight 0.00 lbs
    Price: $99.00

    Choose Size

    Add to cart
    Add to wish list


    Recommended products list
    Customers who bought this product also bought the following products:  
    Your cart Your cart
    Your cart is empty

    View cart
    Wish list
    Orders history

    Authentication Authentication
    Secure login 
    Recover password

    If Javascript is disabled in your browser click here

    Help Help
    Contact us
    Privacy statement
    Terms & Conditions
    About us
    Company news
    Help for new user

    LiveZilla Live Help SiteLock

    Powered by BIOTANG: shopping cart software Copyright © 2006-2015 BIOTANG Inc.